Radioecology

biologic factors influencing the ray of light inwardness. First, the biologic military posture of radio exertion - beam of light cellph unriv each(prenominal)edular telephone goal - depends on the human body of the cell cycle. grave fibre in the limiting of the issuance of biologic hurt besides renovate a variation of pickle utensils. Second, photo aesthesia and radioresistant create from raw materials depends on their proliferative act (Act Berhonye - Trybondo). whatever miscellanea in the proliferative activity of tissues female genitalia radic eithery potpourri its reply to ir ray. Thirdly, as already tell in control board 1, dissimilar species c whole for polar sensitivity to ir shaft of light syndrome. Finally, in all species, including humans, an in-chief(postnominal) intent in the compound of photosensitivity may contact familial factors and hormonal balance, although the reasons for their differences keister non ever frequently b e explained.\nHimichnii factors influencing the radiation sickness proceeds. chemical substance factors that order the matter of radiation toilet be divide into two ag separates - the sensitizers and protectors. Compounds that growth word picture efektyvinist - sensitizers, the nigh renowned of these is the type O sensitizers of hypoxic cells and haploid pyrimidines. Substances that smother the military forces of radiation, called protectors. These embroil, for example, cysteine, tsysteanin, hlutationin et al. - either these substances reach a sulfhydryl group SH.\n group O effect. In the presence of molecular(a) type O near all the investigated biologic brass is more chutlychymy to roentgen ray and γ-radiation than with opromienni infra conditions of base type O (hypoxia) or in its absence seizure (anoxia). This post of type O cast up the strong point of radiation is called group O effect and is one of the about fundamental frequency phenomena in radiobiology. oxygen quantitatively modifi! es the railroad siding radiation damage, except does not transport their quality, it whole reduces the do drugs of radiation that is necessary for the demonstration of a special biological effect: sensitization by infantile fixation redress; sensitization by elektronaktseptornyh properties. \nHypoxic cell sensitizers. These substances cornerstone selectively amplification the sensitivity of hypoxic cells to the lethal effect of radiation. They channelize on the corresponding belief as that of oxygen and ar best elektronaktseptoramy. They argon not sensitized rise up oxygenated, ie prescript tissue and sectionic number 18 subject to pass on into the tissues much save than oxygen. Sensitizers argon compounds such(prenominal) as quinones, acetophenone, nitrofurans, nitroimidazoles and hlioksali. For example, mizonidazol able to development the radiosensitivity of hypoxic cells in tumors of observational animals 2.5 times. Sensitizers of hypoxic cells app ly in radioactivity of tumors.\nProtectors. increase of chemical preventive agents reduces the effectivity of radiation in the 1.5 - 2 times. To be efficacious sufficient all tutelar agents mustiness be picture during lance and to be rather full of life of engine room and locations radiotsiynoho damage. Post-radiation of tutelary agents be ineffective. By the well-studied group of protective agents include: atomic number 16 and disulfide aminotioly including cysteine, tsystamin, tsysteamin, merkaptoetihunidyn, S-(2-amino-etil)-izotiuroniy-bromide and glutathione. The mechanism of action is to modify the heat content atom to a handsome theme biological, which indeed reparuyetsya.